Rapidly advance lead molecules against challenging targets.
Go from B cell to lead molecule in 1 week through direct functional profiling of the B cell repertoire.
Leave no hit behind
In just 1 week, the Opto™ Plasma B Discovery 4.0 workflow enables recovery of 1000s of hits by screening up to 100,000 plasma B cells.
Beacon System And Optoselect Chip
Step 1:
Single-Cell Cloning
Step 2:
Functional Profiling
Step 3:
Barcoded cdna synthesis
Step 4:
Bulk Recovery
Advance the most promising lead molecules by mapping every sequence to antibody function and then use OptoSeq™ Barcoded BCR to recover them all.
>80% of 271 rapidly re-expressed antibodies exhibited antigen specificity in plate-based ELISA assays.
Recover lead molecules, not just sequences
Berkeley Lights’ new Opto™ BCR Rapid Re-expression Kit enables rapid re-expression of antibodies in just 1 week to confirm function in plate-based assays. Amplified cDNA is cloned into expression constructs in one step, enabling expression of thousands of antibodies for rapid functional confirmation.