HYBRIDOMA, PHAGE AND EBV-BASED WORKFLOWS LAST UP TO 3 MONTHS. THE BEACON® PLASMA B CELL WORKFLOW DELIVERS FUNCTIONAL ANTIBODIES IN A SINGLE DAY.
Our plasma B cell workflow identifies only the most qualified antibody leads early in the discovery process, with just a few touchpoints, on a platform that you control.
THE PLASMA B CELL WORKFLOW INTEGRATES 6 STEPS OF A TYPICAL HYBRIDOMA WORKFLOW TO ACCELERATE ANTIBODY DISCOVERY FROM 12 WEEKS TO 1 DAY.
Plasma B cells typically survive for less than a single day. The Beacon workflow enables direct screening of harvested plasma B cells without time-consuming hybridoma generation and screening.
PLASMA B CELL SCREENING
OUR OPTOSELECT™ CHIPS CAN SCREEN THOUSANDS OF PLASMA B CELLS AT THE SAME TIME.
With our OptoSelect chips, you can select rare antibodies by performing high-throughput screening of plasma B cells. Watch how it happens in our videos.
ANTIBODY DISCOVERY ASSAYS
WITH AS LITTLE AS A SINGLE CELL, YOU CAN RUN ASSAYS TO PERFORM IN-DEPTH CHARACTERIZATION OF ANTIBODY FUNCTION.
With a NanoPen™ volume of only 250 picoliters, reactions are fast and precise. Using basic assay building blocks with beads and reporter cells, you can build multiplexed or serial assays to assess antigen-specific binding and function. Better upfront characterization reduces the expense of having to sequence and clone irrelevant, non-functional hits.
LIGAND BLOCKING ASSAY
ANTIGEN SPECIFIC BEAD ASSAY
THE BEACON® PLATFORM PRODUCES A WEALTH OF FUNCTIONAL AND SEQUENCE DATA THAT’S INVALUABLE FOR DISCOVERY OF RARE ANTIBODIES.
With the Beacon plasma B cell workflow, everything you need to connect antibody function to gene sequence at the single-cell level is available. Increase your chances of finding rare functional antibodies (e.g., 0.01% of the plasma B cell repertoire).