Cell Therapy Development: Function You Can See
VISUALIZE DIVERSE CELL INTERACTIONS.
MEASURE INDIVIDUAL CELL CYTOTOXICITY.
RECOVER CELLS OF INTEREST, ALIVE.
SEE HOW THE T CELL PHENOTYPE AND CYTOKINE ASSAY
WORKS IN THIS VIDEO.
PRECISELY ASSEMBLE INDIVIDUAL CELL-CELL INTERACTIONS TO VISUALIZE FUNCTION.
The interaction of cells is a critical step in diverse immune cell functions. The Lightning platform lets you precisely build hundreds of cell-cell interactions to perform highly controlled experiments that isolate and investigate individual cell function. This can be applied across many types of experiments including CAR-T construct screening and validation, antigen or TCR discovery and validation, as well as investigation of regulatory T cell function.
Profile Individual T Cell Function, Phenotype, and Genotype.
Directly pinpointing T cell function is challenging. Linking that function to genotype is even more so. The Lightning platform enables you to determine the activation phenotype (CD137), measure function (IFNγ secretion), and then selectively export cells of interest to sequence TCRs (alpha and beta chain amplification) or for other downstream assays. These capabilities allow you to capture variability in your T cell samples and fully profile them — the first time you look.
EXPORT YOUR FAVORITE CELLS, ALIVE.
You’ve spent time, energy and resources profiling your T cell population. Wouldn’t you like to recover the most interesting individual cells for further characterization? With the Lightning platform, now you can. Evaluate and visualize your cells and data in our Assay Analyzer software and recover the best cells that meet your export criteria.