Get to Market Faster
Every day saved in the development of a biologic equates to financial gain. The Beacon™ platform Cell Line Development Workflow helps to make that goal a reality. In just 5 days, screen 1000s of clones, and export the top 48 clones for scale up with minimal human intervention. Confidently go from individual cells to relevant secretion measurements of clonal cell lines
During typical selection culture, fast growers will overwhelm the population. The Beacon Cell Line Development Workflow allows the sampling of a more diverse population of cells shortly after transfection.
Loading single cells in 1nL pens enables real-time measurement of titer in hours, not weeks. Titer measurements can be tracked through multiple time points in the workflow.
Evaluate thousands of clones based upon your specific criteria: doubling rate, titer, cell diameter, cell circularity, etc.
CHO cells were processed through the cell line development workflow on the Beacon platform. Clones from high, medium, and low titer groups were exported. The exported clones were scaled up to 125 mL shake flasks and titer was measured again. Correlation of titers was seen between the measurements on-chip and from 125 mL flasks.