Antibody Discovery
Lead molecules against any target. At record pace.
Meet the most aggressive timelines
Go from target to lead molecules in weeks not months with the Opto™ Plasma B Discovery 4.0 workflow.
Use this workflow to:
- Recover 1000s of hits by screening up to 100,000 plasma B cells
- Down-select lead molecules by profiling antibody function
- Sequence and re-expression of over 1,000 functionally-characterized antibodies All in just 1 week.
Access greater diversity and deliver the antibodies your clients are looking for
Screen different species and B cell compartments to recover greater antibody sequence diversity.
In a head-to-head comparison, the Opto Plasma B Discovery workflow delivered lead panels that sample >50-fold greater sequence diversity and spanned a wide range of V gene families including all families from which antibodies were discovered via the hybridoma workflow.
Get the full story in our application note.
Succeed against difficult targets
Increase the probability of success against difficult and high-value targets by directly screening B cells with assays to identify functional lead molecules.
Direct functional profiling of B cells can yield up to 10-fold more hits than hybridoma campaigns against difficult membrane targets like GPCRs.
Want to learn more about how the Opto Plasma B Discovery workflow can help you get to the clinic faster? Fill out the short form below and a specialist will be in touch within 24 hours.