Antibody Discovery
Broadly neutralizing antibodies target the coronavirus fusion peptide
Science
Dacon, Cherrelle... Tan, Joshua
The potential for future coronavirus outbreaks highlights the need to develop strategies and tools to broadly target this group of pathogens. Here, using an...
A large-scale systematic survey reveals recurring molecular features of public antibody responses to SARS-CoV-2
Immunity
Wang, Yiquan, Y... Wu, Nicholas C
Global research to combat the COVID-19 pandemic has led to the isolation and characterization of thousands of human antibodies to the SARS-CoV-2 spike protein,...
Single-Cell Technologies for the Study of Antibody-Secreting Cells
Frontiers in Immunology
Broketa, Matteo... Bruhns, Pierre
Antibody-secreting cells (ASC), plasmablasts and plasma cells, are terminally differentiated B cells responsible for large-scale production and secretion of antibodies. ASC are derived from...
Single B cell technologies for monoclonal antibody discovery
Trends in Immunology
Pedrioli, A;Oxenius, A
Monoclonal antibodies (mAbs) are often selected from antigen-specific single B cells derived from different hosts, which are notably short-lived in ex vivo culture conditions...
Bispecific antibodies targeting distinct regions of the spike protein potently neutralize SARS-CoV-2 variants of concern
Science Translational Medicine
Cho, Hyeseon... Tan, Joshua
The emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants of concern threatens the efficacy of existing vaccines and therapeutic antibodies and underscores...
Miniaturized single-cell technologies for monoclonal antibody discovery
Lab on a Chip
Van Lent... Lammertyn, J
Antibodies (Abs) are among the most important class of biologicals, showcasing a high therapeutic and diagnostic value. In the global therapeutic Ab market, fully-human...
Novel Monoclonal Antibodies and Recombined Antibodies Against Variant SARS-CoV-2
Frontiers in Immunology
Xie, Jiajia... Gao, Yong
The mutants resulted from the ongoing SARS-CoV-2 epidemic have showed resistance to antibody neutralization and vaccine-induced immune response. The present study isolated and identified...
Convergent antibody responses to the SARS-CoV-2 spike protein in convalescent and vaccinated individuals
Cell Reports
Chen, Elaine C... Crowe, James E
Unrelated individuals can produce genetically similar clones of antibodies, known as public clonotypes, which have been seen in responses to different infectious diseases, as...
A global consortium, next-generation SARS-CoV-2 antibody therapeutics and stabilized spike
Acta Crystallographica Section A Foundations and Advances
Saphire, Erica, E
Our group also undertook an antibody discovery effort using the Berkeley Lights Beacon instrument with structural biology-grade antigens to isolate highly potent antibodies...
Accelerated antibody discovery targeting the SARS-CoV-2 spike protein for COVID-19 therapeutic potential
Antibody Therapeutics
Mullen, Tracey E... Souders, Colby A
Rapid deployment of technologies capable of high-throughput and high-resolution screening is imperative for timely response to viral outbreaks. Risk mitigation in the form of...
Therapeutic Antibodies Targeting Potassium Ion Channels
Handbook of Experimental Pharmacology
Bednenko, Janna... Clark, Theodore
Monoclonal antibodies combine specificity and high affinity binding with excellent pharmacokinetic properties and are rapidly being developed for a wide range of drug targets...
Structural basis for SARS-CoV-2 neutralizing antibodies with novel binding epitopes
PLoS Biology
Fu, Dan, D... Guo, Yu, Y
The ongoing Coronavirus Disease 2019 (COVID-19) pandemic caused by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) threatens global public health and economy unprecedentedly, requiring...
Ultrapotent bispecific antibodies neutralize emerging SARS-CoV-2 variants
bioRxiv
Cho, Hyeseon... Tan, Joshua
The emergence of SARS-CoV-2 variants that threaten the efficacy of existing vaccines and therapeutic antibodies underscores the urgent need for new antibody-based tools that...
COVID-19 update: The race to therapeutic development
Drug Resistance Updates
Twomey, JD;Luo, S;Dean, AQ;Bozza, WP;Nalli, A;Zhang, B
The COVID-19 pandemic, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), represents an unprecedented challenge to global public health. At the time of...
Emerging Strategies for Therapeutic Antibody Discovery from Human B Cells
Advances in Experimental Medicine and Biology
Rajan, S; Dall'Acqua, WF
Monoclonal antibodies from human sources are being increasingly recognized as valuable options in many therapeutic areas. These antibodies can show exquisite specificity and high...
Rapid isolation and profiling of a diverse panel of human monoclonal antibodies targeting the SARS-CoV-2 spike protein
Nature Medicine
Seth J. Zost... James E. Crowe Jr.
Antibodies are a principal determinant of immunity for most RNA viruses and have promise to reduce infection or disease during major epidemics. The novel...
Taking Cell Lines to the Bank
Genetic Engineering & Biotechnology News
Kathy Liszewski
In biopharmaceutical development, master cell banks reward those who invest in cell line optimization Cell line development is preparing to let go of its...
Single-Cell Protein Secretion Detection and Profiling
Annual Review of Analytical Chemistry
Chen, Z;Chen, JJ;Fan, R
Secreted proteins play important roles in mediating various biological processes such as cell-cell communication, differentiation, migration, and homeostasis at the population or tissue level....