Antibody Discovery

Publication 07/12/2022

Broadly neutralizing antibodies target the coronavirus fusion peptide

Science

Dacon, Cherrelle... Tan, Joshua

The potential for future coronavirus outbreaks highlights the need to develop strategies and tools to broadly target this group of pathogens. Here, using an...

Publication 03/25/2022

A large-scale systematic survey reveals recurring molecular features of public antibody responses to SARS-CoV-2

Immunity

Wang, Yiquan, Y... Wu, Nicholas C

Global research to combat the COVID-19 pandemic has led to the isolation and characterization of thousands of human antibodies to the SARS-CoV-2 spike protein,...

Publication 01/31/2022

Single-Cell Technologies for the Study of Antibody-Secreting Cells

Frontiers in Immunology

Broketa, Matteo... Bruhns, Pierre

Antibody-secreting cells (ASC), plasmablasts and plasma cells, are terminally differentiated B cells responsible for large-scale production and secretion of antibodies. ASC are derived from...

Publication 12/01/2021

Single B cell technologies for monoclonal antibody discovery

Trends in Immunology

Pedrioli, A;Oxenius, A

Monoclonal antibodies (mAbs) are often selected from antigen-specific single B cells derived from different hosts, which are notably short-lived in ex vivo culture conditions...

Publication 10/20/2021

Bispecific antibodies targeting distinct regions of the spike protein potently neutralize SARS-CoV-2 variants of concern

Science Translational Medicine

Cho, Hyeseon... Tan, Joshua

The emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants of concern threatens the efficacy of existing vaccines and therapeutic antibodies and underscores...

Publication 09/28/2021

Miniaturized single-cell technologies for monoclonal antibody discovery

Lab on a Chip

Van Lent... Lammertyn, J

Antibodies (Abs) are among the most important class of biologicals, showcasing a high therapeutic and diagnostic value. In the global therapeutic Ab market, fully-human...

Publication 08/30/2021

Novel Monoclonal Antibodies and Recombined Antibodies Against Variant SARS-CoV-2

Frontiers in Immunology

Xie, Jiajia... Gao, Yong

The mutants resulted from the ongoing SARS-CoV-2 epidemic have showed resistance to antibody neutralization and vaccine-induced immune response. The present study isolated and identified...

Publication 08/24/2021

Convergent antibody responses to the SARS-CoV-2 spike protein in convalescent and vaccinated individuals

Cell Reports

Chen, Elaine C... Crowe, James E

Unrelated individuals can produce genetically similar clones of antibodies, known as public clonotypes, which have been seen in responses to different infectious diseases, as...

Publication 07/30/2021

A global consortium, next-generation SARS-CoV-2 antibody therapeutics and stabilized spike

Acta Crystallographica Section A Foundations and Advances

Saphire, Erica, E

Our group also undertook an antibody discovery effort using the Berkeley Lights Beacon instrument with structural biology-grade antigens to isolate highly potent antibodies...

Publication 07/01/2021

Accelerated antibody discovery targeting the SARS-CoV-2 spike protein for COVID-19 therapeutic potential

Antibody Therapeutics

Mullen, Tracey E... Souders, Colby A

Rapid deployment of technologies capable of high-throughput and high-resolution screening is imperative for timely response to viral outbreaks. Risk mitigation in the form of...

Publication 05/08/2021

Therapeutic Antibodies Targeting Potassium Ion Channels

Handbook of Experimental Pharmacology

Bednenko, Janna... Clark, Theodore

Monoclonal antibodies combine specificity and high affinity binding with excellent pharmacokinetic properties and are rapidly being developed for a wide range of drug targets...

Publication 05/01/2021

Structural basis for SARS-CoV-2 neutralizing antibodies with novel binding epitopes

PLoS Biology

Fu, Dan, D... Guo, Yu, Y

The ongoing Coronavirus Disease 2019 (COVID-19) pandemic caused by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) threatens global public health and economy unprecedentedly, requiring...

Publication 04/01/2021

Ultrapotent bispecific antibodies neutralize emerging SARS-CoV-2 variants

bioRxiv

Cho, Hyeseon... Tan, Joshua

The emergence of SARS-CoV-2 variants that threaten the efficacy of existing vaccines and therapeutic antibodies underscores the urgent need for new antibody-based tools that...

Publication 12/01/2020

COVID-19 update: The race to therapeutic development

Drug Resistance Updates

Twomey, JD;Luo, S;Dean, AQ;Bozza, WP;Nalli, A;Zhang, B

The COVID-19 pandemic, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), represents an unprecedented challenge to global public health. At the time of...

Publication 09/19/2020

Emerging Strategies for Therapeutic Antibody Discovery from Human B Cells

Advances in Experimental Medicine and Biology

Rajan, S; Dall'Acqua, WF

Monoclonal antibodies from human sources are being increasingly recognized as valuable options in many therapeutic areas. These antibodies can show exquisite specificity and high...

Publication 07/10/2020

Rapid isolation and profiling of a diverse panel of human monoclonal antibodies targeting the SARS-CoV-2 spike protein

Nature Medicine

Seth J. Zost... James E. Crowe Jr.

Antibodies are a principal determinant of immunity for most RNA viruses and have promise to reduce infection or disease during major epidemics. The novel...

Publication 11/23/2019

Taking Cell Lines to the Bank

Genetic Engineering & Biotechnology News

Kathy Liszewski

In biopharmaceutical development, master cell banks reward those who invest in cell line optimization Cell line development is preparing to let go of its...

Publication 06/12/2019

Single-Cell Protein Secretion Detection and Profiling

Annual Review of Analytical Chemistry

Chen, Z;Chen, JJ;Fan, R

Secreted proteins play important roles in mediating various biological processes such as cell-cell communication, differentiation, migration, and homeostasis at the population or tissue level....