Synthetic Biology
Massively parallel quantification of phenotypic heterogeneity in single-cell drug responses
Science Advances
Yellen, Benjamin B... Hammerbacher, Jeff
Single-cell analysis tools have made substantial advances in characterizing genomic heterogeneity; however, tools for measuring phenotypic heterogeneity have lagged due to the increased difficulty...
Foundational Tools for Building a New Bioeconomy
Journal of Commercial Biotechnology
Levine, Daniel S
While biotechnology has been transforming the diagnosis and treatment of disease, it has also been altering everything from the production of crops to how...
High-throughput optofluidic screening for improved microbial cell factories via real-time micron-scale productivity monitoring
Lab on a Chip
Rienzo, Matthew... Leavell, Michael D
The industrial synthetic biology sector has made huge investments to achieve relevant miniaturized screening systems for scalable fermentation. Here we present the first example...
Emerging optofluidic technologies for biodiagnostic applications
VIEW
Wu, Jiandong... Lin, Francis
For continuous-flow PCR, recent advances have been made toward several directions: (1) _Operation simplification and system integration_. For example, Tachibana et al. developed continuous-flow PCR...
Sensing the future of bio-informational engineering
Nature Communications
Dixon, Thomas A... Pretorius, Isak S
The practices of synthetic biology are being integrated into 'multiscale' designs enabling two-way communication across organic and inorganic information substrates in biological, digital and...
High-throughput screening for high-efficiency small-molecule biosynthesis
Metabolic Engineering
Rienzo, Matthew... Leavell, Michael D
Systems metabolic engineering faces the formidable task of rewiring microbial metabolism to cost-effectively generate high-value molecules from a variety of inexpensive feedstocks for many...
High-throughput screening for improved microbial cell factories, perspective and promise
Current opinion in biotechnology
Leavell, Michael D... Kaufmann-Malaga, Benjamin B
High-throughput screening is a critical part of any industrial strain engineering effort, helping ensure the lowest cost product is produced in the shortest amount...
Microfluidic Cell Sorting and Separation Technology
Microsystems and Nanosystems
Lee, Wonhee... Di Carlo, Dino
Cell sorting and separation is widely used as a critical first step for research and clinical applications where it is needed to isolate individual...