All Publications

Publication 07/12/2022

Broadly neutralizing antibodies target the coronavirus fusion peptide

Science

Dacon, Cherrelle... Tan, Joshua

The potential for future coronavirus outbreaks highlights the need to develop strategies and tools to broadly target this group of pathogens. Here, using an...

Publication 04/01/2022

Response under pressure: deploying emerging technologies to understand B-cell-mediated immunity in COVID-19

Nature Methods

Woodruff, Matthew C... Sanz, Ignacio

Critical technological advances have enabled the rapid investigations into the immune responses elicited by SARS-CoV-2, the pathogen responsible for the COVID-19 pandemic. We discuss...

Publication 04/01/2022

Traceable impedance-based single-cell pipetting, from a research set-up to a robust and fast automated robot: DispenCell-S1

SLAS Technology

Hannart, Héloïse, H... Bonzon, David, D

Single-cell isolation is a truly transformative tool for the understanding of biological systems. It allows single-cell molecular analyses and considers the heterogeneity of cell...

Publication 03/25/2022

A large-scale systematic survey reveals recurring molecular features of public antibody responses to SARS-CoV-2

Immunity

Wang, Yiquan, Y... Wu, Nicholas C

Global research to combat the COVID-19 pandemic has led to the isolation and characterization of thousands of human antibodies to the SARS-CoV-2 spike protein,...

Publication 03/17/2022

Single-cell analysis of circulating tumour cells: enabling technologies and clinical applications

Trends in Biotechnology

Radfar, Payar... Warkiani, Majid Ebrahimi

Multimodal analysis of circulating tumour cells (CTCs) has the potential to provide remarkable insight for cancer development and metastasis. CTCs and CTC clusters investigation...

Publication 01/31/2022

Single-Cell Technologies for the Study of Antibody-Secreting Cells

Frontiers in Immunology

Broketa, Matteo... Bruhns, Pierre

Antibody-secreting cells (ASC), plasmablasts and plasma cells, are terminally differentiated B cells responsible for large-scale production and secretion of antibodies. ASC are derived from...

Publication 12/01/2021

Single B cell technologies for monoclonal antibody discovery

Trends in Immunology

Pedrioli, A;Oxenius, A

Monoclonal antibodies (mAbs) are often selected from antigen-specific single B cells derived from different hosts, which are notably short-lived in ex vivo culture conditions...

Publication 12/01/2021

A review: Dielectrophoresis for characterizing and separating similar cell subpopulations based on bioelectric property changes due to disease progression and therapy assessment

Electrophoresis

Duncan, Josie L... Davalos, Rafael V

This paper reviews the use of dielectrophoresis for high-fidelity separations and characterizations of subpopulations to highlight the recent advances in the electrokinetic field as...

Publication 11/01/2021

High-throughput and automation advances for accelerating single-cell cloning, monoclonality and early phase clone screening steps in mammalian cell line development for biologics production

Biotechnology Progress

Tejwani, Vijay, V... Sharfstein, Susan T

Mammalian cell line development is a multistep process wherein timelines for developing clonal cells to be used as manufacturing cell lines for biologics production...

Publication 11/01/2021

Microfluidic chip-based single-cell cloning to accelerate biologic production timelines

Biotechnology Progress

Diep, Jonathan, J... Stevens, Jennitte, J

Cell line development (CLD) represents a critical, yet time-consuming, step in the biomanufacturing process as significant resources are devoted to the scale-up and screening...

Publication 10/29/2021

Single-cell electrical characterization

Biosensors for Single-Cell Analysis

Cottet, Jonathan... Caselli, Federica

This chapter provides an introduction to single-cell electrical characterization techniques and related devices, which play a key role in the framework of label-free biosensing...

Publication 10/20/2021

Bispecific antibodies targeting distinct regions of the spike protein potently neutralize SARS-CoV-2 variants of concern

Science Translational Medicine

Cho, Hyeseon... Tan, Joshua

The emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants of concern threatens the efficacy of existing vaccines and therapeutic antibodies and underscores...

Publication 09/28/2021

Miniaturized single-cell technologies for monoclonal antibody discovery

Lab on a Chip

Van Lent... Lammertyn, J

Antibodies (Abs) are among the most important class of biologicals, showcasing a high therapeutic and diagnostic value. In the global therapeutic Ab market, fully-human...

Publication 09/17/2021

Massively parallel quantification of phenotypic heterogeneity in single-cell drug responses

Science Advances

Yellen, Benjamin B... Hammerbacher, Jeff

Single-cell analysis tools have made substantial advances in characterizing genomic heterogeneity; however, tools for measuring phenotypic heterogeneity have lagged due to the increased difficulty...

Publication 09/02/2021

Foundational Tools for Building a New Bioeconomy

Journal of Commercial Biotechnology

Levine, Daniel S

While biotechnology has been transforming the diagnosis and treatment of disease, it has also been altering everything from the production of crops to how...

Publication 08/30/2021

Novel Monoclonal Antibodies and Recombined Antibodies Against Variant SARS-CoV-2

Frontiers in Immunology

Xie, Jiajia... Gao, Yong

The mutants resulted from the ongoing SARS-CoV-2 epidemic have showed resistance to antibody neutralization and vaccine-induced immune response. The present study isolated and identified...

Publication 08/24/2021

Convergent antibody responses to the SARS-CoV-2 spike protein in convalescent and vaccinated individuals

Cell Reports

Chen, Elaine C... Crowe, James E

Unrelated individuals can produce genetically similar clones of antibodies, known as public clonotypes, which have been seen in responses to different infectious diseases, as...

Publication 08/07/2021

High-throughput optofluidic screening for improved microbial cell factories via real-time micron-scale productivity monitoring

Lab on a Chip

Rienzo, Matthew... Leavell, Michael D

The industrial synthetic biology sector has made huge investments to achieve relevant miniaturized screening systems for scalable fermentation. Here we present the first example...