All Publications
Convergent antibody responses to the SARS-CoV-2 spike protein in convalescent and vaccinated individuals
Cell Reports
Chen, Elaine C... Crowe, James E
Unrelated individuals can produce genetically similar clones of antibodies, known as public clonotypes, which have been seen in responses to different infectious diseases, as...
High-throughput optofluidic screening for improved microbial cell factories via real-time micron-scale productivity monitoring
Lab on a Chip
Rienzo, Matthew... Leavell, Michael D
The industrial synthetic biology sector has made huge investments to achieve relevant miniaturized screening systems for scalable fermentation. Here we present the first example...
Emerging optofluidic technologies for biodiagnostic applications
VIEW
Wu, Jiandong... Lin, Francis
For continuous-flow PCR, recent advances have been made toward several directions: (1) _Operation simplification and system integration_. For example, Tachibana et al. developed continuous-flow PCR...
A global consortium, next-generation SARS-CoV-2 antibody therapeutics and stabilized spike
Acta Crystallographica Section A Foundations and Advances
Saphire, Erica, E
Our group also undertook an antibody discovery effort using the Berkeley Lights Beacon instrument with structural biology-grade antigens to isolate highly potent antibodies...
Accelerated antibody discovery targeting the SARS-CoV-2 spike protein for COVID-19 therapeutic potential
Antibody Therapeutics
Mullen, Tracey E... Souders, Colby A
Rapid deployment of technologies capable of high-throughput and high-resolution screening is imperative for timely response to viral outbreaks. Risk mitigation in the form of...
Nanoscale integration of single cell biologics discovery processes using optofluidic manipulation and monitoring
Biotechnology and Bioengineering
Jorgolli, Marsela ... Miranda, Less P.
The new and rapid advancement in the complexity of biologics drug discovery has been driven by a deeper understanding of biological systems combined with...
Therapeutic Antibodies Targeting Potassium Ion Channels
Handbook of Experimental Pharmacology
Bednenko, Janna... Clark, Theodore
Monoclonal antibodies combine specificity and high affinity binding with excellent pharmacokinetic properties and are rapidly being developed for a wide range of drug targets...
Structural basis for SARS-CoV-2 neutralizing antibodies with novel binding epitopes
PLoS Biology
Fu, Dan, D... Guo, Yu, Y
The ongoing Coronavirus Disease 2019 (COVID-19) pandemic caused by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) threatens global public health and economy unprecedentedly, requiring...
Preclinical development of a molecular clamp-stabilised subunit vaccine for severe acute respiratory syndrome coronavirus 2
Wiley Online Library
Watterson, Daniel... Chappel, Keith J
Efforts to develop and deploy effective vaccines against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) continue at pace. Here, we describe rational antigen design...
Ultrapotent bispecific antibodies neutralize emerging SARS-CoV-2 variants
bioRxiv
Cho, Hyeseon... Tan, Joshua
The emergence of SARS-CoV-2 variants that threaten the efficacy of existing vaccines and therapeutic antibodies underscores the urgent need for new antibody-based tools that...
Sensing the future of bio-informational engineering
Nature Communications
Dixon, Thomas A... Pretorius, Isak S
The practices of synthetic biology are being integrated into 'multiscale' designs enabling two-way communication across organic and inorganic information substrates in biological, digital and...
High-throughput screening for high-efficiency small-molecule biosynthesis
Metabolic Engineering
Rienzo, Matthew... Leavell, Michael D
Systems metabolic engineering faces the formidable task of rewiring microbial metabolism to cost-effectively generate high-value molecules from a variety of inexpensive feedstocks for many...
Limited Mitochondrial Activity Coupled With Strong Expression of CD34, CD90 and EPCR Determines the Functional Fitness of ex vivo Expanded Human Hematopoietic Stem Cells
Frontiers in Cell and Developmental Biology
Papa, L... Hoffman, R
Ex vivo expansion strategies of human hematopoietic stem cell (HSC) grafts with suboptimal stem cell dose have emerged as promising strategies for improving outcomes...
COVID-19 update: The race to therapeutic development
Drug Resistance Updates
Twomey, JD;Luo, S;Dean, AQ;Bozza, WP;Nalli, A;Zhang, B
The COVID-19 pandemic, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), represents an unprecedented challenge to global public health. At the time of...
Recent advances in CHO cell line development for recombinant protein production
Science Direct
Borbála Tihany, LászlóNyitra
Recombinant proteins used in biomedical research, diagnostics and different therapies are mostly produced in Chinese hamster ovary cells in the pharmaceutical industry. These biotherapeutics,...
Emerging Strategies for Therapeutic Antibody Discovery from Human B Cells
Advances in Experimental Medicine and Biology
Rajan, S; Dall'Acqua, WF
Monoclonal antibodies from human sources are being increasingly recognized as valuable options in many therapeutic areas. These antibodies can show exquisite specificity and high...
A singular view of COVID-19
Nature Biotechnology
Eisenstein, M
Single-cell analysis sheds light on immune response to COVID-19 infection, enables the rapid discovery of antibody leads, and points to ways to get ahead...
Advances in single cell technologies in immunology
BioTechniques
Choi, JR
The immune system is composed of heterogeneous populations of immune cells that regulate physiological processes and protect organisms against diseases. Single cell technologies have...