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All Publications

Publication 08/24/2021

Convergent antibody responses to the SARS-CoV-2 spike protein in convalescent and vaccinated individuals

Cell Reports

Chen, Elaine C... Crowe, James E

Unrelated individuals can produce genetically similar clones of antibodies, known as public clonotypes, which have been seen in responses to different infectious diseases, as...

Publication 08/07/2021

High-throughput optofluidic screening for improved microbial cell factories via real-time micron-scale productivity monitoring

Lab on a Chip

Rienzo, Matthew... Leavell, Michael D

The industrial synthetic biology sector has made huge investments to achieve relevant miniaturized screening systems for scalable fermentation. Here we present the first example...

Publication 08/01/2021

Emerging optofluidic technologies for biodiagnostic applications


Wu, Jiandong... Lin, Francis

For continuous-flow PCR, recent advances have been made toward several directions: (1) _Operation simplification and system integration_. For example, Tachibana et al. developed continuous-flow PCR...

Publication 07/30/2021

A global consortium, next-generation SARS-CoV-2 antibody therapeutics and stabilized spike

Acta Crystallographica Section A Foundations and Advances

Saphire, Erica, E

Our group also undertook an antibody discovery effort using the Berkeley Lights Beacon instrument with structural biology-grade antigens to isolate highly potent antibodies...

Publication 07/01/2021

Accelerated antibody discovery targeting the SARS-CoV-2 spike protein for COVID-19 therapeutic potential

Antibody Therapeutics

Mullen, Tracey E... Souders, Colby A

Rapid deployment of technologies capable of high-throughput and high-resolution screening is imperative for timely response to viral outbreaks. Risk mitigation in the form of...

Publication 05/21/2021

Nanoscale integration of single cell biologics discovery processes using optofluidic manipulation and monitoring

Biotechnology and Bioengineering

Jorgolli, Marsela ... Miranda, Less P.

The new and rapid advancement in the complexity of biologics drug discovery has been driven by a deeper understanding of biological systems combined with...

Publication 05/08/2021

Therapeutic Antibodies Targeting Potassium Ion Channels

Handbook of Experimental Pharmacology

Bednenko, Janna... Clark, Theodore

Monoclonal antibodies combine specificity and high affinity binding with excellent pharmacokinetic properties and are rapidly being developed for a wide range of drug targets...

Publication 05/01/2021

Structural basis for SARS-CoV-2 neutralizing antibodies with novel binding epitopes

PLoS Biology

Fu, Dan, D... Guo, Yu, Y

The ongoing Coronavirus Disease 2019 (COVID-19) pandemic caused by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) threatens global public health and economy unprecedentedly, requiring...

Publication 04/05/2021

Preclinical development of a molecular clamp-stabilised subunit vaccine for severe acute respiratory syndrome coronavirus 2

Wiley Online Library

Watterson, Daniel... Chappel, Keith J

Efforts to develop and deploy effective vaccines against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) continue at pace. Here, we describe rational antigen design...

Publication 04/01/2021

Ultrapotent bispecific antibodies neutralize emerging SARS-CoV-2 variants


Cho, Hyeseon... Tan, Joshua

The emergence of SARS-CoV-2 variants that threaten the efficacy of existing vaccines and therapeutic antibodies underscores the urgent need for new antibody-based tools that...

Publication 01/15/2021

Sensing the future of bio-informational engineering

Nature Communications

Dixon, Thomas A... Pretorius, Isak S

The practices of synthetic biology are being integrated into 'multiscale' designs enabling two-way communication across organic and inorganic information substrates in biological, digital and...

Publication 01/01/2021

High-throughput screening for high-efficiency small-molecule biosynthesis

Metabolic Engineering

Rienzo, Matthew... Leavell, Michael D

Systems metabolic engineering faces the formidable task of rewiring microbial metabolism to cost-effectively generate high-value molecules from a variety of inexpensive feedstocks for many...

Publication 12/15/2020

Limited Mitochondrial Activity Coupled With Strong Expression of CD34, CD90 and EPCR Determines the Functional Fitness of ex vivo Expanded Human Hematopoietic Stem Cells

Frontiers in Cell and Developmental Biology

Papa, L... Hoffman, R

Ex vivo expansion strategies of human hematopoietic stem cell (HSC) grafts with suboptimal stem cell dose have emerged as promising strategies for improving outcomes...

Publication 12/01/2020

COVID-19 update: The race to therapeutic development

Drug Resistance Updates

Twomey, JD;Luo, S;Dean, AQ;Bozza, WP;Nalli, A;Zhang, B

The COVID-19 pandemic, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), represents an unprecedented challenge to global public health. At the time of...

Publication 12/01/2020

Recent advances in CHO cell line development for recombinant protein production

Science Direct

Borbála Tihany, LászlóNyitra

Recombinant proteins used in biomedical research, diagnostics and different therapies are mostly produced in Chinese hamster ovary cells in the pharmaceutical industry. These biotherapeutics,...

Publication 09/19/2020

Emerging Strategies for Therapeutic Antibody Discovery from Human B Cells

Advances in Experimental Medicine and Biology

Rajan, S; Dall'Acqua, WF

Monoclonal antibodies from human sources are being increasingly recognized as valuable options in many therapeutic areas. These antibodies can show exquisite specificity and high...

Publication 09/01/2020

A singular view of COVID-19

Nature Biotechnology

Eisenstein, M

Single-cell analysis sheds light on immune response to COVID-19 infection, enables the rapid discovery of antibody leads, and points to ways to get ahead...

Publication 09/01/2020

Advances in single cell technologies in immunology


Choi, JR

The immune system is composed of heterogeneous populations of immune cells that regulate physiological processes and protect organisms against diseases. Single cell technologies have...