Fast, powerful workflow for antibody discovery
Reduce AbD timelines and downstream costs by screening B cells for function in a single day and taking only the best candidates forward.
Screen thousands of clones in parallel and select top clones for even non-traditional antibody molecules, like bispecifics.
Enabling simple yet powerful AbD workflows
The Beacon Select for AbD system enables game changing process improvements for simultaneous incubation and screening of thousands of clones on a chip
AbD workflows find winners quickly and flexibly
Functionally screen tens of thousands of B cells on a chip simultaneously.
Customize your assays to find your best antibodies
Assays for soluble and membrane-bound targets can be customized and run sequentially and/or in multiplex with Opto B Discovery on Beacon Select. Leverage multiple fluorophores, detection molecules, and your available antigens to screen B cells in minutes to hours, not months.
Beacon technology
At the core of the Beacon Select system is a combination of optics and nanofluidics called optofluidics
The OptoSelect® chips replace typical well plates. Each OptoSelect chip contains thousands of NanoPen® chambers, which are like wells on a microplate. This is where cells are deposited, where they grow and where they are characterized using a myriad of proprietary PhenomeX assays.
Beacon Workflow Modules
Screening thousands of cells is an automated process on the Beacon system with our four workflow modules: Import, Culture, Assay and Export. These modules can be adapted, interchanged and deployed with a variety of single-cell assays to address specific applications and a variety of cell types.
Import
Our software automatically identifies single cells and directs them into NanoPen chambers all at once. Chips are loaded with cells in less than 30 minutes.
Culture
As cells proliferate, nutrients diffuse in, waste diffuses out, and software images the chip continuously to count cells and calculate growth rate.
Assay
Test individual cells immediately and repeatedly in our NanoPen® chambers, instead of culturing for weeks to reach a minimum number of cells for assay.
Export
Choose your cells of interest. Light patterns move them into position for export to a well plate.
Recover lead molecules, not just sequences
Re-express >1,000 antibodies in 1 week without gene synthesis and cloning.
The Opto BCR Rapid Re-expression kit converts antibody sequences into molecules in just 1 week for plate-based confirmation assays. Amplified cDNA is cloned into expression constructs in one step, enabling expression of >1,000 antibodies for rapid functional confirmation.
Contact us to learn more about the Beacon Select system
Related Resources
View All Beacon System ResourcesBROCHURE: Beacon Select™ Optofluidic System for CLD
- Approximately half the price of the 4-chip Beacon system
- A 2-chip automated optofluidic system, similar to the 4-chip Beacon® optofluidic system, which provides well-established workflows that have been adopted by ~130 customers
- Throughput scaled to meet the needs of small to mid-sized biopharma and CDMO/CRO companies
DATASHEET: Opto® Memory B Discovery Rabbit Workflow
- Rapid workflow to screen rabbit memory B cells to discover high-value monoclonal antibodies
- Robust activation of rabbit memory B cells using proprietary feeder-free activation media
- Efficient recovery of antigen-specific antibody sequences for downstream characterization and development
DATASHEET: Opto® Plasma B Discovery 4.0 Workflow
- Recovery of 1,000s of hits from over 40,000 individual plasma B cells in a single 4-chip workflow
- Down-selection of lead candidates by functional profiling
- Sequencing and re-expression of >1,000 functionally-characterized antibodies
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