Imagine how much further you can take your product development with a single cell-based workflow that shortens the selection process to just days. Bring the right biologic therapies into clinical testing faster. Identify the cells that matter much sooner. Move any field light-years ahead.
Beacon system enables game changing process improvements and is most popular for the following workflows. Pick your workflow and see the difference:
The Beacon system can capture bright field and fluorescence images of each NanoPen™ in an OptoSelect™ chip at any time. Track and assay the same individual cell across multiple time points to reveal deep profiling—richly detailed “fingerprints” of cells and clones you can’t get any other way.
The OptoSelect chips replace typical well plates. Each OptoSelect chip contains thousands of NanoPen chambers, which are like wells on a microplate. This is where cells are deposited, where they grow and where they are characterized using a myriad of proprietary Berkeley Lights assay.
Screening 1000s of cells is an automated and process process on the Beacon system with our four workflow modules: Import, Culture, Assay and Export. These modules can be adapted, interchanged and deployed with a variety of single-cell assays to address specific applications and a variety of cell types.
Our software automatically identifies single cells and directs them into NanoPen chambers all at once. Chips are loaded with cells in less than 30 minutes.
As cells proliferate, nutrients diffuse in, waste diffuses out, and software images the chip continuously to count cells and calculate growth rate.
Test individual cells immediately and repeatedly in our NanoPen chambers, instead of culturing for weeks to reach a minimum number of cells for assay.
Choose your cells of interest. Light patterns move them into position for export to a well plate.
That means a single cell can be isolated and assayed in its own discrete chamber. There’s no need to wait weeks for a large quantity of cells to assay. Perform secretion assays with both soluble or membrane bound targets within hours of cloning. You have complete flexibility to run fully-automated assays, sequentially or simultaneously, as frequently as you choose.
Depending on your assay and throughput needs, different chips with different throughput and NanoPen chamber shapes are available for the Beacon system. You can run up to 4 chips at the same time and the Culture Station instrument can be used for culturing cells on chips offline.
1.7 nL NanoPen chambers are ideal for longer term culture experiments including cell line development and adherent cell cloning.
0.75 nL NanoPen chambers enable some cell division and higher clone throughput.
0.32 nL NanoPens are designed for the highest throughput of single cell screening.
Discover how the Beacon system shortens timelines, simplifies workflows and reveals detailed data through deep profiling.
Learn how you can increase scope, scale, and throughput of workflows run on the Beacon and Lightning platforms.
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